Faculty

Cody Eric Bünger
President
SICOT Foundation
Past President
Nordic Orthopaedic Federation



CV:
Personal data
Birthday 230848
Address Department of Orthopedics E, Århus University Hospital. Nørrebrogade 44, Bld. 21, 8000 Århus C
Position: Professor, Chief Surgeon, Director of Orthopedic Research Lab, Head of Spine Section.
E-mail:
codybung@rm.dk Website: www.orf-aarhus.dk Phone
+45 8949 4111

Academic experience
1975:
Medical degree from Aarhus University; 1975 ECFMG United States medical degree; 1987: Doctoral thesis Aarhus
University; 1992: Appointed Professor of Orthopedic Surgery, University of Aarhus; 1992: Head of the Dept. of Spine
Surgery, University Hospital of Aarhus; 1995: The Peter Moll Professor of Orthopedic Surgery, University of Cape Town,
South Africa; 1995: Full Profesor of Orthopedic Surgery, Aarhus University; 1996: Visiting Professor, Henry Ford Hospital,
Detroit, USA; 2001: Director of Nanoscience and Biocompatibility Group (STF). 2008 Director of Strategic International Research Program: Individualized Regeneration and Repair of the Musculoskeletal System; 2009 Director of Strategic National Program: Cost-Effectiveness in Spine Surgery

Collegial appointments
1975-77
Elected member of the Danish Young Doctors Association Council; 09/1990 Elected Danish National Delegate
for SICOT; 1996 Quality Assurance Board of Danish Medical Association: Board of Directors 1998 Consultant to the
Killian Research Board in Canada; 1998-06 National project on disc surgery; 1998–01 Danish representative, UEMS;
2002
Consultant to the Dutch Medical Research Council; 2006 Founding member of international study group of spinal
deformities IGASS; 2006 Finance Committee EFFORT; 2011 Active fellow Scoliosis Research Society;
2010 Member of ISSLS (The International Society for the Study of the Lumbar Spine)

Evaluation committees: Professorships in Orthopaedics
1999
Oslo; 2000 Ping University, Lindkjøbing; 2004 Lund University; 2006 Hong Kong; 2007 Karolinska Institute; 2008 Sahlgrenska University; 2009 Lund University; 2010 Lund University

Presidencies and Chairmanships
1982-present
Chairman of Orthopedic Research Group, Aarhus University Hospital; 1991-2001 Scientific Board and
Board of Directors of the National Rheumatism Association; 1992 Editorial Board. Injury; 1993-96 President of the
Scandinavian Scoliosis Society; 1994-96 President of the Scandinavian Orthopedic Research Society; 1997-2000 Chairman
of the Educational Commitee, Danish Orthopedic Society; 1997-2007 Host of Traveling Fellows program of the European
Spinal Society and GICD; 1998-05 Board of Directors. Institute for Clinical Medicine, University of Aarhus;
1998-06
Editorial Board. Acta Orthopaedica; 2000 Founding member. Global Spine Tumour Study Group; 1993-1995 President of Nordic Spinal Society; 2001 Director of Nanoscience and Biocompatability Research STF, University of Aarhus; 2003 President-elect Danish Orthopedic Society; 2003 Director of 6th Framework IP EU program application; 2004 Director of EU/Chinese program 973; 2005 President-elect SICOT; 2005 Scientific Board Faculty of Health AU; 2006 President of Danish Orthopedic Society;
2008 Vicepresident of NOF; 2008-2011 President of SICOT; 2010 President of NOF

Advisory and Supervisory functions

1983 & 1985 Gold medal university projects in orthopedic surgery
1991 – 2006 Diploma studies & examinations:
13
1985 – 2011
Master’s Theses:
30
S Harving 1985, J Lyhne 1985, I Holm 1986, H Evald
1986, F B Christensen 1987, M Lind 1988, C Glavind 1998, C Becker 1998, W Drescher 1998, F Seiling 1998, L Bundgaard 1998, T B Jensen 1999, O Rahbek 1999, M Bünger 2001, T Andersen 2001, C Woo 2003, A Greis 2004, P Bucholtz 2005, M Bendtsen 2005, L Thomassen 2007, M Axelsen 2007, C Foldager, E Glavind 2008, K Hjermitslev 2008, J Jensen 2008, J Rölfing 2009, U Boyer Christensen 2009, S M Bach 2010, B Christensen 2010, A K Knudsen 2011
Ongoing Master’s theses 3
Heidi Dyrop, Nina McKinnon Edwards, Sarah Stammose Freund
PhD studies & theses 27
S Jespersen, B E Lindblad, A Lundgaard 1999, J F Møller, H Tromborg, M Lind 1994, F B Christensen 1997, T B Jensen, W Drescher 2001, M Laursen 2001, O Rahbek 2002, Z Xuenong 2003, T Schneider (Düsseldorff), H Li 2004, Xue Qingyun 2004, M Stiehler 2006, T Andersen 2006, K Weigert 2006, M Bünger 2007, Zou Lijin 2007, R Søgaard 2007, L Bjerre 2009, M Bendtsen 2009, T Lindkjær Jensen 2009, T S Videbæk 2010, M Chen 2011, C Tvedesøe 2011
Ongoing PhD studies 15
Lisa Ø Gregersen, Dang Le, Casper Foldager, Jan Rölfing, Jonas Jensen, Efe Levent Aras, Miao Wang, Shallu Shama, Kristian Høy, Samir Munir, Halldór B Einarsson, Yu Wang, Ming Sun, Kresten Rickers, Ulla Munksgaard Stahlschmidt
1993-2006 Doctoral dissertations 6
K Søballe 1993, J Keller 1994, M Lind 1998, ES Hansen 1999, S Overgaard 2000, FB Christensen 2005
Ongoing doctoral dissertations 6
M Bendtsen, B E Lindblad, Li Haisheng, Zou Xuenong, Thomas Andersen, Yu Wang

Awards and Main Grants
1993 John H. Moe award: Scoliosis Research Society. 1997 Volvo Award; 1998 Karl Hoffa Preis. 1998 Orthopedic Research
Society: New Investigator Recognition Award; 2000 International College of Angiology: Young Investigator Award in
Basic Research; 1998, 2000, 2002, 2003, 2004, 2005 Danish Orthopedic Society Best Paper Award;
2001
Danish National
Research Board grant for Nanoscience and Biocompatability Research project (US $3,000,000); 2003 Anna & Jacob
Jacobsens Scholarship (for pioneer work in the field of spinal surgery); 2003 European Spine Society Grammar Award Euro 25,000 (best research paper of the year); 2004 Knighted by the Danish Queen; 2004 German Rheumaorthopaedic Association “Arthur Vick-Preis for Rheumaorthopaedics”; 2005 The Danish Research Council 2.5 million DKR; 2005 Velux Foundation Grant 2.3 million DKR DKR; 2005 A P Møller and Wife’s Foundation Grant 10.2 million DKR; 2006 ISSLS Prize Award; 2006 Best EuroSpine Podium Presentation; 2006 Danfoss Fund 1.5 million DKR;  2006  Forskningsrådet for Sundhed og Sygdom grant 1.9
million DKR kr.; 2006 Forsknings- og Innovationsstyrelsen grant 1.8 million DKR; 2007
Lundbeck Fonden Grant 0.8 million DKR; 2007 The Strategic Research Council Grant 8.7 million DKR; 2008 The Strategic Research Council Grant 10.1 million DKR; 2008 Aarhus University Fond o.5 million DKR; 2008 Velux Foundation 2.7 million DKR; 2009 Medico prize; 2009 Lundbeck Foundation LUNA 30.3 million DKR.

Patents and Inventions
U.S. Patent Application (No 20050272153):
Bone Tissue Engeering by ex vivo Stem Cells Ongrowth into Three-Dimensional Trabecular metal. Inventors: Zou X, Li H, Bünger C. EU Patent submitted (EU NO: 09163896.5):: Three-dimentional Nanostructured Hybrid Scaffold and Manufacture Thereof. Inventors: Bjerre L, Nygaard JV, Besenbacher F, Bünger C. Patent Number(s): US2008033548-A1 New three-dimensional tissue scaffold-implant, useful for supporting tissue on-growth, for forming tissue, or for bone regeneration. Inventors: Xuenong Z, Li H, Bünger C. Patent Number(s): US2005272153-A1 New three-dimensional tissue scaffold-implant for supporting tissue on-growth comprising a lattice, biocompatible material and growth factor, useful for bone regeneration. Inventors Xuenong Z, Li H; Bünger C. Invention no: AU -2010-634-392): Rongyao: A surgical instrument for Navigated Percutanous Lumbosacral Interbody fusion procedure. Inventors: Le D,  Wang Y, Bünger C. Patent Application No. PCT/DK2010/050125: Submerged Perfusion Bioreactor (SURFBREAC). Inventors: Nygaard JV, Foss M, Besenbacher F, Bünger C. Patent No. AU-2010-634-393: GRAded Structure TUbulaR Freeze-gelled (GRASTURF) scaffolds and a continous method for making same”: Inventors: Le D, Mortensen M, Hasenkam M, Besenbacher F, Bünger C. 

Scientific publications
(papers & articles in scientific journals 1974-present): 285 including 202 in Pubmed
Invited Guest Lectures: 121

Selected Publications within the last 2 years
2011

1     Chondrocyte Gene Expression is Affected by Very Small Iron Oxide Particles-Labeling in Long-Term in Vitro MRI Tracking. Casper Bindzus Foldager, BMSc,1,2* Michael Pedersen, MSc, PhD,3 Steffen Ringgaard, MSc, PhD,3 Cody Bünger, MD, DMSc,1 and Martin Lind, MD, PhD, DMSc2
2     Bjerre L, Bünger C, Baatrup A, Kassem M, Mygind T.
Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes. J Biomed Mater Res A. 2011 Jun 1;97(3):251-63. doi: 10.1002/jbm.a.33051. Epub 2011 Mar 25. PMID:21442726
3     Dolatshahi-Pirouz A, Jensen TH, Kolind K, Bünger C, Kassem M, Foss M, Besenbacher F.
Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces. Colloids Surf B Biointerfaces. 2011 May 1;84(1):18-25. Epub 2010 Dec 8. PMID: 21237623 [PubMed - indexed for MEDLINE]
4     Christensen BB, Foldager CB, Hansen OM, Kristiansen AA, Le DQ, Nielsen AD, Nygaard JV, Bünger CE, Lind M.
A novel nano-structured porous polycaprolactone scaffold improves hyaline cartilage repair in a rabbit model compared to a collagen type I/III scaffold: in vitro and in vivo studies. Knee Surg Sports Traumatol Arthrosc. 2011 Oct 5. [Epub ahead of print]PMID: 21971941 [PubMed - as supplied by publisher]
5     Jensen T, Baas J, Dolathshahi-Pirouz A, Jacobsen T, Singh G, Nygaard JV, Foss M, Bechtold J, Bünger C, Besenbacher F, Søballe K.
Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation. J Biomed Mater Res A. 2011 Oct;99(1):94-101. doi: 10.1002/jbm.a.33166. Epub 2011 Jul 28. PMID: 21800419 [PubMed - in process]

2010
Andersen T, Christensen FB, Høy KW, Helmig P, Niedermann B, Hansen ES, Bünger C.
The predictive value of pain drawings in lumbar spinal fusion surgery. Spine J. 2010 May;10(5):372-9.
Andersen T, Christensen FB, Langdahl BL, Ernst C, Fruensgaard S, Ostergaard J, Andersen JL, Rasmussen S, Niedermann B, Høy K, Helmig P, Holm R, Lindblad BE, Hansen ES, Egund N, Bünger C.
Fusion mass bone quality after uninstrumented spinal fusion in older patients. Eur Spine J. 2010 Dec;19(12):2200-8. Epub 2010 Apr 29.
Choi D, Crockard A, Bunger C, Harms J, Kawahara N, Mazel C, Melcher R, Tomita K. Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group. Eur Spine J. 2010 Feb;19(2):215-22.
Jensen T, Dolatshahi-Pirouz A, Foss M, Baas J, Lovmand J, Duch M, Pedersen FS, Kassem M, Bünger C, Søballe K, Besenbacher 2F. Interaction of human mesenchymal stem cells with osteopontin coated hydroxyapatite surfaces Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):186-93. Epub 2009 Aug 25
Andersen MO, Nygaard JV, Burns JS, Raarup MK, Nyengaard JR, Bünger C, Besenbacher F, Howard KA, Kassem M, Kjems J.
siRNA Nanoparticle Functionalization of Nanostructured Scaffolds Enables Controlled Multilineage Differentiation of Stem Cells. Mol Ther. 2010 Aug 31. [Epub ahead of print]PMID: 20808289
Jensen T, Jakobsen T, Baas J, Nygaard JV, Dolatshahi-Pirouz A, Hovgaard MB, Foss M, Bünger C, Besenbacher F, Søballe K.
Hydroxyapatite nanoparticles in poly-D,L-lactic acid coatings on porous titanium implants conducts bone formation. J Biomed Mater Res A. 2010 Dec 1;95(3):665-72.
Videbaek TS, Bünger CE, Henriksen M, Egund N, Christensen FB.
Sagittal Spinal Balance After Lumbar Spinal Fusion: The Impact of Anterior Column Support: Results From a Randomized Clinical Trial With an Eight- to Thirteen-Year Radiographic Follow-up. Spine (Phila Pa 1976). 2010 Aug 5. [Epub ahead of print]PMID: 20693941.
Jensen J, Foldager CB, Jakobsen TV, Søballe K, Bünger C, Baas J.
Use of carboxymethyl cellulose and collagen carrier with equine bone lyophilisate suggests late onset bone regenerative effect in a humerus drill defect - a pilot study in six sheep. Open Orthop J. 2010 May 11;4:181-7.PMID: 20582241
Wang Y, Bünger C, Hanse ES, et. Al. Distal adding-on Phenomenon in Lenke 1A Type Scolioses: Risk Factor Identification and Treatment Strategy Comparison. Phila Pa 1976). 2011 Jan 14.
Wang Y, Bünger C, Le DQS, et al. Navigated Percutaneous Lumbosacral Interbody Fusion: a feasibility study with 3D surgical simulation and cadaveric experiment. Spine Phila Pa 1976). 2011 Feb 1.
Michael Bendtsen, Cody Eric Bünger, Xuenong Zou, Casper Foldager, Hans Stødkilde Jørgensen. Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental IDD. Spine (Phila Pa 1976). 2010 Dec 29.
Bendtsen M, Zou X, Haisheng L, Jørgensen HS, Bünger CE. An Experimental Large Animal Model of Intervertebral Disc Degeneration: Charaterized by MRI, Ultrasound, X-Ray, and Histology. (Submitted for Acta Orthopaedica).
Bendtsen M, Zou X, Haisheng L, Jørgensen HS, Bünger CE. Anti TNF-alpha does not Augment the Effect of Autologous Mesenchymal Stem Cell Therapyin Experimental Early Intervertebral Disc Degeneration. (Submitted for Spine).
Bendtsen M, Zou X, Haisheng L, Jørgensen HS, Bünger CE. Structural Vertebral Endplate Changes in Experimental Disc Degeneration measured by microCT, Diffusion tensor imaging, and Real Time RT-PCR. (Submitted for Bone).
Bendtsen M, Zou X, Haisheng L, Jørgensen HS, Bünger CE. Vertebral Endplate Perfusion in Autologous Stem Cell Therapy of Experimental Early Intervertebral Disc Degeneration. (Submitted for Radiology).
Videbaek TS, Egund N, Christensen FB, Grethe Jurik A, Bünger CE.
Adjacent segment degeneration after lumbar spinal fusion: the impact of anterior column support: a randomized clinical trial with an eight- to thirteen-year magnetic resonance imaging follow-up. Spine Phila Pa 1976). 2010 Oct 15;35(22):1955-64.
Chen M, Le DQ, Baatrup A, Nygaard JV, Hein S, Bjerre L, Kassem M, Zou X, Bünger C.
Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering. Acta Biomater. 2010 Dec 31.
Xue Q, Li H, Zou X, Dalstra M, Lind M, Christensen FB, Bünger C.
Alendronate treatment improves bone-pedicle screw interface fixation in posterior lateral spine fusion: an experimental study in a porcine model. Int Orthop. 2010 Mar;34(3):447-51. Epub 2009 Mar 28. PMID: 19330331 [PubMed - indexed for MEDLINE]

2009
Andersen T, Christensen FB, Ernst C, Fruensgaard S, Ostergaard J, Andersen J L, Rasmussen S, Niedermann B, Hoy, K, Helmig P, Holm Randi, Lindblad BE, Hansen ES, Egund N, Bunger C: The Effect of Electrical Stimulation on Lumbar Spinal Fusion in Older Patients: A Randomized, Controlled, Multi-Center Trial Part 1: Functional Outcome. SPINE, Oct 1 2009, 34(21)
: 2241-2247.      
Andersen T, Christensen FB, Ernst C, Fruensgaard S, Ostergaard J, Andersen J L, Rasmussen S, Niedermann B, Hoy, K, Helmig P, Holm Randi, Lindblad BE, Hansen ES, Egund N, Bunger C: The Effect of Electrical Stimulation on Lumbar Spinal Fusion in Older Patients: A Randomized, Controlled, Multi-Center Trial Part 2: Fusion Rate. SPINE Oct 1 2009, 34(21): 2248-2253.    
Foldager CB, Munir S, Ulrik-Vinther M, Søballe K, Bünger C, Lind M.
Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes. BMC Mol Biol. 2009 Oct 9;10:94.
Qingyun Xue, Cody Bünger. Alendronate Treatment does not Inhibit Biphasic Calcium Phosphate Material Substitution in Posterior Lateral Spine Fusion:
  An experimental Study in Porcine Model. Chinese medical journal, pub. 2009, 122(22): 2770-2774.
Casper Bindzus Foldager, Samir Munir, Michael Ulrik-Vinther, Kjeld Søballe, Cody Bünger and Martin Lind. Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes. BMC Molecular Biology 2009, 10:94, doi:10.1186/1471-2199-10-94.
Sogaard R; Christensen FB, Videbaek TS, et al. Interchangeability of the EQ-5D and the SF-6D in Long-Lasting Low Back Pain. VALUE IN HEALTH  12(4):606-612, jun. 2009. 
Schneider T, Cremer D, Becker C, Hansen ES, Bünger C, Drescher W. Femoral head histology subsequent to ischemia, reperfusion, and steroid treatment.  Ann Anat. 2009 Jul 25. 191(5):496-501.  
Andersen T, Christensen FB, Niedermann B, Helmig P, Høy K, Hansen ES, Bünger C. Impact of instrumentation in lumbar spinal fusion in elderly patients. Acta Orthop. 2009 Jan, 80(4)445-450.
Chen M, Feng W, Cao H, Zou L, Chen C, Baatrup A, Nielsen AB, Li H, Kassem M, Zou X, Bünger C. A traditional Chinese medicine formula extracts stimulate proliferation and inhibit mineralization of human mesenchymal stem cells in vitro. J Ethnopharmacol. 2009 Aug 17;125(1):75-82.
Foldager C, Bendtsen M. PET scanning for evaluation of bone metabolism. ACTA ORTHOPAEDICA,  2009, 80(6): 737-738.      
Foldager C, Bendtsen M, Nygaard JV, Zou X, Bünger C. Differences in Early Osteogenesis and Bone Micro-architecture in Anterior Lumbar Interbody Fusion with rhBMP-2, Equine Bone Protein Extract, and Autograft. Bone. 2009 May 3, 45(2): 267-273.
Xue Q, Li H, Zou X, Dalstra M, Lind M, Christensen FB, Bünger C: Alendronate Treatment Improves Bone-pedicle Screw Interface Fixation in Posterior Lateral Spine Fusion: An Experimental Study in a Porcine Model. Int Orthop. 2009 Mar 28.
Zou X, Zou L, Foldager C, Bendtsen M, Feng W, Bünger CE. Different Mechanisms of Spinal Fusion using Equine Bone Protein Extract, rhBMP-2 and Autograft during the Process of Anterior Lumbar Interbody Fusion. Biomaterials. 2009 Feb; 30(6):991-1004.
Stiehler M, Bünger C, Baatrup A, Lind M, Kassem M, Mygind T. Effect of Dynamic 3-D Culture on Proliferation, Distribution, and Osteogenic Differentiation of Human Mesenchymal Stem Cells.  J Biomed Mater Res A. 2009 Apr; 89(1):96-107